Endocrine Abstracts

We present the case of a woman who first presented at age 18 with hirsutism. Menarche had been normal and she had regular menses. She gave no past medical history except that at age 6 she had been admitted to hospital with tonsillitis that was complicated by diarrhoea and vomiting, drowsiness and hypotension. At that time, Na+ was 130 mmol/l and K+5.8 mmol/l. She was treated with antibiotics and fluids and improved; electrolytes returned to normal.<p ...

Background: Circulating levels of total oestradiol (E2) decrease with age in adult males; the effect of altered E2 circadian rhythm is uncertain. We hypothesised that age-related changes in the circadian rhythm contribute to decreased BMD in older males and investigated this.Methods: Nineteen subjects were studied: six young-healthy (YH) males (mean age (years) 27.3±4.6) with normal BMD, eight older-healthy (OH) males (mean age...

A 57-year-old man with a history of alcohol excess was admitted following a road traffic accident. He suffered multiple trauma with fractures to his left femur, tibia and fibula, his right pubic ramus and several ribs. In addition severe abdominal trauma necessitated nephrectomy and splenectomy. Routine biochemistry and bone profile on admission was within normal limits.He had a prolonged stay in the Intensive Therapy Unit (ITU) with acute kidney injury ...

A 22-year-old woman with hypophosphataemic rickets was diagnosed at age four when she presented with short stature and valgus deformity of the lower limbs. Biochemical testing, genetic screening and radiological investigation of her family showed no abnormality and it was concluded that she had a de novo mutation.She was treated with 1α-calcidol and phosphate Sandoz with regularly monitored biochemistry. She had poor adherence to her medicati...